CME Sessions at EANM’08

EANM’08 – CME Session II

October 12, 2008, 11:30 – 13:00
Instrumentation and Methodology in Multi-Centre Trials

Moderator: A. Britten (London)
Co-Moderator: T. Sera (Szeged)

L. Geworski (Berlin) and B. Knoop (Hannover):
Multi-Centre Trials with PET: Physical Prerequisites
T. Sera (Szeged):
Inter-Laboratory Comparison SPECT Studies with Phantoms
M. Lassmann (Wuerzburg):
Multi-Centre Trials involving Radionuclide Therapy

Educational objectives:

  1. To be aware of the issues to do with instrumentation and methodology when taking part in, or organizing, a multi-centre trial involving Nuclear Medicine.
  2. The participant will be aware of the importance of standardization, and the need for comparative Quality Assurance of the imaging being performed. The material will include the processing and analysis of data.
  3. In addition, the participant will learn of the issues relating to the application and assessment of radionuclide therapy in multi-centre trials.


Increasingly multi-centre trials are being recognized as essential to determine the effect and value of therapies and diagnostic procedures. Such trials allow recruitment of larger numbers of patients, and also are more realistic to the final application since many operators with different equipment are involved.
Studies that are intended to investigate a Nuclear Medicine procedure need to consider carefully the effects of different equipment and ensure that these effects do not confuse the experimental design.
In this session the issues to do with studies with PET and SPECT systems will be explained, as well as information on the issues with trials of radionuclide therapy, such as activity measurement and radiation dose estimation.

Key Words:

Multi-centre trials, methodology, instrumentation

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