CTE Sessions at EANM’10

EANM’10 – CTE Session I

October 10, 2010, 08:15 – 09:45
Dynamic Imaging in Cardiology

Moderators: W.van den Broek (Nijmegen), S. Steien (Elverum)

H.Verberne (Amsterdam):
123I-meta-iodobenzylguanidine in patients with chronic heart failure: technical aspects, conceptual issues, and future prospects
B. Zerahn (Herlev):
Application of SPECT-CT in coronary artery disease
P. De Bondt (Aalst):
Recent developments in processing and interpreting gated perfusion and gated blood pool SPECT studies

Educational objectives:

Upon completion of this session the attendee will have an understanding of:

  1. Know the value of 123I-MIBG scintigraphy in the diagnosis of chronic heart failure.
  2. Explain how to use myocardial 123I-MIBG scintigraphy in clinical routine.
  3. Understand the principles of myocardial perfusion and blood flow, factors determining flow, coronary flow regulation, vasoreactivity, coronary flow reserve, regional flow differences, and flow variability.
  4. Know the value of perfusion imaging in the diagnosis, prognosis, and management of patients with coronary artery disease.
  5. Explain the advantages of combined SPECT/CT in the diagnostic management of Coronary artery disease.
  6. Know the value of gated blood pool SPECT ventricular function measurements in LVEF measurements.


Cardiovascular diseases are the number one cause of death and disability in most European countries. Heart failure is a condition in which the heart can no longer pump enough blood to the rest of the body and is almost always a chronic, long-term condition. Early diagnosis and predictive value may help in the intervention of the disease. 123I-MIBG seems to be promising in the identifying those patients with heart failure at risk.

Perhaps the most common cause of heart failure is coronary artery disease (CAD), a narrowing of the small blood vessels that supply blood and oxygen to the heart. Whereas MSCT has the advantage to detect coronary atherosclerosis at its earliest stages, myocardial perfusion imaging can clarify the hemodynamic consequences on a functional assessment of myocardial blood flow The current use of hybrid systems as SPECT/CT makes it possible to get anatomical and functional information in a one stop shop.

Quantative information of the function of main chamber of the heart, the left ventricle, is often important in the management of cardiotoxic chemotherapy. Decreased left ventricular ejection fraction (LVEF) is a relative contraindication for the use of potentially cardiotoxic chemotherapy. Validation of Gated blood pool SPECT ventricular function measurements may help to reliable results in the measurement of LVEF. Lung, Lung Embolism, Diagnostics, Imaging Modalities, SPECT, CTA, Ventilation, Perfusion, Chest Radiography

Key Words:

131I-MIBG, chronic heart failure, coronary artery disease, SPECT/CT, gated blood pool SPECT, LVEF measurement

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