CTE Sessions at EANM’12

EANM’12 – Mini Course II

October 28, 2012, 15:45 – 16:45
SPECT-CT in Neuroendocrine Tumours

Moderator: C. Peştean (Cluj-Napoca), D. Mansi (Milan)


Speakers:
extended
abstract
D. Piciu (Cluj-Napoca):
SPECT-CT in Neuroendocrine Tumours – a Clinical Overview
C.A. Hoefnagel (Amsterdam):
SPECT-CT in Neuroendocrine Tumours – a Real Imaging Tool; Applications and Benefits


Educational objectives:

  1. To identify the clinical aspects of the pathology from the field of neuro-endocrine oncology in which SPECT-CT could add a diagnostic value in the therapeutic strategy.
  2. To find a therapeutic overview of neuroendocrine tumours in which SPECT-CT has a real clinical utility.
  3. To highlight the applications and benefits of SPECT-CT as a diagnostic option in NET.
  4. To discover the available radiopharmaceutical options used by SPECT-CT in NET.
  5. To observe differences between radiopharmaceuticals used by SPECT-CT in neuroendocrine tumours.
  6. To identify important technical aspects concerning different SPECT-CT imaging alternatives in the diagnostic of neuroendocrine tumours.


Summary:

Neuroendocrine tumours are a heterogeneous group of tumours arising from neuroendocrine cells, and include carcinoid, non-carcinoid gastro-enteropancreatic tumours, catecholamine-secreting tumours, medullary carcinoma of the thyroid, chromophobe pituitary tumours, small cell lung cancer and Merkel cell tumours, etc.

They are well known for producing various hormonal syndromes and for their indolent clinical course, although some of these tumours do not produce hormones of clinical significance. Nuclear medicine plays an important role in the evaluation of patients with neuroendocrine tumours. Scintigraphic exams with radiolabeled somatostatin analogues and metaiodobenzylguanidine (MIBG) give important information on receptor expression, functional status, metabolism, and tissue viability of these neoplasms.

When, by multimodal imaging methods like SPECT-CT, this information are combined with cross-sectional anatomical information, an important diagnostic value arises. Structural and functional images became complementary and lead to additional clinical information imposing structural anatomical framework on functional images.


Key Words:

Neuroendocrine Tumours, SPECT-CT, In-111 Octreotide, MIBG, Radiopharmaceutical, Somatostatin Receptor Scintigraphy, Multimodal Imaging

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