CTE Sessions at EANM’14

EANM’14 – CTE Session IV

October 20, 2014, 16:30 – 18:00
Preclinical Studies in Nuclear Medicine

Chairpersons: P. Fragoso Costa (Oldenburg), S. Del Vecchio (Naples)

A. v. Thaden (Munich):
Animal Handling Procedures
J.-P. Dillenseger (Strasburg):
Technologist Involvement in Pre-Clinical Studies
M. Martic-Kehl (Zurich):
The Challenges of Translational Animal Research

Educational Objectives:

  1. Acquire general knowledge of handling, application, blood taking and anaesthetic techniques on small animals
  2. Identify the relevance of Animal care in the context of pre-clinical imaging
  3. Get acquainted with the extended technologist competences as a member of a pre-clinical team
  4. Identify future challenges and opportunities
  5. Recognize the impact of nuclear medicine techniques in pre-clinical trials
  6. Describe the pitfalls and problems of animal research as a tool for the implementation in Human medicine


Pre-clinical imaging is an emerging field of great importance for several research areas. Nuclear Medicine imaging techniques allow a non-invasive in-vivo quantification of biochemical processes in animal models using labelled biomarkers. Pre-clinical imaging is also a multidisciplinary modality, in which professionals from different backgrounds get to work in the same team. This session will expose this reality and give an insight to practical and technical aspects of pre-clinical daily procedures. Focus will also be given to the actual position of Nuclear Medicine in pre-clinical imaging, its limitations and future prospects.
Traditionally, lymphoscintigraphy has been used to preoperatively identify sentinel nodes in breast cancer and other malignant tumours. A few years ago SPECT/CT was introduced in nuclear medicine and has been used in some hospitals to anatomically localise sentinel nodes. In this presentation it will be described when sentinel lymph node scintigraphy in breast cancer is required, how it can be done, when additional SPECT/CT is needed and what the advantages are.
Respiratory gated CT scans for radiotherapy planning of breast cancer can be performed in inspiration, either as inspiration gating or as deep inspiration breath hold. Radiotherapy for breast cancer is typically delivered as two opposing tangential fields, encompassing the breast. The lung tissue adjacent to the breast is therefore included in the radiation fields, representing a risk of late lung toxicity. For the left sided breast cancer, the heart may be partially inside the irradiated area as well, resulting in high risk of cardiac toxicity as a late effect of radiotherapy. In deep or moderate inspiration, the total lung volume inflates considerately, reducing the dose to the whole lung, while the heart moves caudally away from the irradiated area and considerably decreases the risk of cardiac toxicity.

Key Words:

Pre-Clinical Imaging, Animals, Research, Challenges and Opportunities

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